The actin cytoskeletal architecture of estrogen receptor positive breast cancer cells suppresses invasion.

ABSTRACT: Estrogen promotes growth of estrogen receptor-positive (ER+) breast tumors. However, epidemiological studies examining the prognostic characteristics of breast cancer in postmenopausal women receiving hormone replacement therapy reveal a significant decrease in tumor dissemination, suggesting that estrogen has potential protective effects against cancer cell invasion. Here, we show that estrogen suppresses invasion of ER+ breast cancer cells by increasing transcription of the Ena/VASP protein, EVL, which promotes the generation of suppressive cortical actin bundles that inhibit motility dynamics, and is crucial for the ER-mediated suppression of invasion in vitro and in vivo. Interestingly, despite its benefits in suppressing tumor growth, anti-estrogenic endocrine therapy decreases EVL ex

SUBMITTER: Padilla-Rodriguez M 

PROVIDER: S-EPMC6065369 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature