Identifying autophagy gene-associated module biomarkers through construction and analysis of an autophagy-mediated ceRNA‑ceRNA interaction network in colorectal cancer.

ABSTRACT: Autophagy is crucial in cellular homeostasis and has been implicated in the development of malignant tumors. However, the regulatory function of autophagy in cancer remains to be fully elucidated. In the present study, the autophagy-mediated competing endogenous RNA (ceRNA)‑ceRNA interaction networks in colorectal cancer (CRC) were constructed by integrating systematically expression profiles of long non‑coding RNAs and mRNAs. It was found that a large proportion of autophagy genes were inclined to target hub nodes, including a fraction of autophagy genes, by comparing with other genes within ceRNA networks, and showed preferential interaction with themselves. The present study also revealed that autophagy genes may be used as prognostic markers for cancer therapy. A risk score model based

SUBMITTER: Qian K 

PROVIDER: S-EPMC6065403 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature