Transition Metal Sequestration by the Host-Defense Protein Calprotectin.

ABSTRACT: In response to microbial infection, the human host deploys metal-sequestering host-defense proteins, which reduce nutrient availability and thereby inhibit microbial growth and virulence. Calprotectin (CP) is an abundant antimicrobial protein released from neutrophils and epithelial cells at sites of infection. CP sequesters divalent first-row transition metal ions to limit the availability of essential metal nutrients in the extracellular space. While functional and clinical studies of CP have been pursued for decades, advances in our understanding of its biological coordination chemistry, which is central to its role in the host-microbe interaction, have been made in more recent years. In this review, we focus on the coordination chemistry of CP and highlight studies of its metal-binding

SUBMITTER: Zygiel EM 

PROVIDER: S-EPMC6066180 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature