Microglia increases the proliferation of retinal precursor cells during postnatal development.

ABSTRACT:

Purpose

In mice, retinal development continues throughout the postnatal stage accompanied by the proliferation of retinal precursor cells. Previous reports showed that during the postnatal stage microglia increase from postnatal day 0 (P0) to P7. However, how microglia are associated with retinal development remains unknown.

Methods

The involvement of microglia in retinal development was investigated by two approaches, microglial activation and loss, using lipopolysaccharide (LPS) and PLX3397 (pexidartinib), respectively.

Results

LPS injection at 1 mg/kg, intraperitoneally (i.p.) in the neonatal mice increased the number of retinal microglia at P7. 5-Bromo-2´-deoxyuridine (BrdU)-positive proliferative cells were increased by LPS treatment compared to the control group

SUBMITTER: Kuse Y 

PROVIDER: S-EPMC6066272 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature