The plant cysteine oxidases from Arabidopsis thaliana are kinetically tailored to act as oxygen sensors.

ABSTRACT: Group VII ethylene response factors (ERF-VIIs) regulate transcriptional adaptation to flooding-induced hypoxia in plants. ERF-VII stability is controlled in an O₂-dependent manner by the Cys/Arg branch of the N-end rule pathway whereby oxidation of a conserved N-terminal cysteine residue initiates target degradation. This oxidation is catalyzed by plant cysteine oxidases (PCOs), which use O₂ as cosubstrate to generate Cys-sulfinic acid. The PCOs directly link O₂ availability to ERF-VII stability and anaerobic adaptation, leading to the suggestion that they act as plant O₂ sensors. However, their ability to respond to fluctuations in O₂ concentration has not been established. Here, we investigat

SUBMITTER: White MD 

PROVIDER: S-EPMC6066304 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature