A brain-enriched Drp1 isoform associates with lysosomes, late endosomes, and the plasma membrane.

ABSTRACT: Dynamin-related protein 1 (Drp1) constricts mitochondria as a mechanochemical GTPase during mitochondrial division. The Drp1 gene contains several alternative exons and produces multiple isoforms through RNA splicing. Here we performed a systematic analysis of Drp1 transcripts in different mouse tissues and identified a previously uncharacterized isoform that is highly enriched in the brain. This Drp1 isoform is termed Drp1_ABCD because it contains four alterative exons: A, B, C, and D. Remarkably, Drp1_ABCD is located at lysosomes, late endosomes, and the plasma membrane in addition to mitochondria. Furthermore, Drp1_ABCD is concentrated at the interorganelle interface between mitochondria and lysosomes/late endosomes. The localizations of Drp1_ABCD

SUBMITTER: Itoh K 

PROVIDER: S-EPMC6066318 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature