Clinical outcomes of prolonged infusion (extended infusion or continuous infusion) versus intermittent bolus of meropenem in severe infection: A meta-analysis.

ABSTRACT:

Background

Meropenem exhibits time-dependent antimicrobial activity and prolonged infusion (PI) (extended infusion or continuous infusion, EI or CI) of meropenem can better achieve pharmacodynamics target when comparing with intermittent bolus (IB). However, the clinical outcomes between two groups remain inconclusive.

Objective

To evaluate current published literatures by meta-analysis to ascertain whether PI of meropenem can improve clinical outcomes.

Methods

Medline, Cochrane database and EMBASE were searched. Randomized control trails (RCT) and observational studies which compared the clinical outcomes of PI and IB groups were included and evaluated for quality. The data of studies were extracted and meta-analysis was performed using Revman 5.3 software.

Result

SUBMITTER: Yu Z 

PROVIDER: S-EPMC6066326 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature