Maternal Plasma per- and Polyfluoroalkyl Substance Concentrations in Early Pregnancy and Maternal and Neonatal Thyroid Function in a Prospective Birth Cohort: Project Viva (USA).

ABSTRACT:

Background

Prenatal exposure to some per- and polyfluoroalkyl substances (PFASs) may disrupt maternal and neonatal thyroid function, which is critical for normal growth and neurodevelopment.

Objectives

We examined associations of PFAS exposure during early pregnancy with maternal and neonatal thyroid hormone levels.

Methods

We studied 732 mothers and 480 neonates in Project Viva, a longitudinal prebirth cohort in Boston, Massachusetts. We quantified six PFASs, including perfluorooctanoic acid (PFOA) and perfluorooctane sulfonate (PFOS), and maternal thyroid hormones [thyroxine (T₄), Free T₄ Index (FT₄I), thyroid stimulating hormone (TSH)] in plasma samples collected at a median 9.6 wk gestation and neonatal T₄ levels from po

SUBMITTER: Preston EV 

PROVIDER: S-EPMC6066354 | biostudies-literature | 2018 Feb

REPOSITORIES: biostudies-literature