Quantitative assessment of binding affinities for nanoparticles targeted to vulnerable plaque.

ABSTRACT: Recent successes in targeted immune and cell-based therapies have driven new directions for pharmaceutical research. With the rise of these new therapies there is an unfilled need for companion diagnostics to assess patients' potential for therapeutic response. Targeted nanomaterials have been widely investigated to fill this niche; however, in contrast to small molecule or peptide-based targeted agents, binding affinities are not reported for nanomaterials, and to date there has been no standard, quantitative measure for the interaction of targeted nanoparticle agents with their targets. Without a standard measure, accurate comparisons between systems and optimization of targeting behavior are challenging. Here, we demonstrate a method for quantitative assessment of the binding affinity f

SUBMITTER: Tang T 

PROVIDER: S-EPMC6066368 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature