Exposures to Air Pollution and Risk of Acute-onset Placental Abruption: A Case-crossover Study.

ABSTRACT:

Background

Despite abruption's elusive etiology, knowledge of triggers that precede it by just a few days prior to delivery may help to understand the underpinnings of this acute obstetrical complication. We examine whether air pollution exposures immediately preceding delivery are associated with acute-onset abruptions.

Methods

We applied a bidirectional, time-stratified, case-crossover design to births with an abruption diagnosis in New York City, 2008-2014. We measured ambient fine particulate matter (PM2.5) and nitrogen dioxide (NO2). We fit distributed lag nonlinear models based on conditional logistic regression to evaluate individual exposure and cumulative exposures over lags 0-7 days before abruption, adjusted for temperature and relative humidity (similar lags to t

SUBMITTER: Ananth CV 

PROVIDER: S-EPMC6066409 | biostudies-literature | 2018 Sep

REPOSITORIES: biostudies-literature