GABRA2 rs279858-linked variants are associated with disrupted structural connectome of reward circuits in heroin abusers.

ABSTRACT: The reward system plays a vital role in drug addiction. The purpose of this study is to investigate the structural connectivity characteristics and driving-control subnetwork patterns of reward circuits in heroin abusers and assess the genetic modulation on the reward network. We first defined the reward network based on systematic literature review, and built the reward network based on diffusion tensor imaging data of 78 heroin abusers (HAs) and 79 healthy controls (HCs) using structural connectomics. Then we assessed genetic factors that might modulate changes in the reward network by performing imaging-genetic screening for 22 addiction-related polymorphisms. The genetic association was validated by performing genetic associations (1032 HAs and 2863 HCs) and expanded-variant analysis.

SUBMITTER: Sun Y 

PROVIDER: S-EPMC6066482 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature