Measurement of ⁶⁸Ga-DOTATOC Uptake in the Thoracic Aorta and Its Correlation with Cardiovascular Risk.

ABSTRACT:

Purpose

⁶⁸Ga-labeled 1,4,7,10-tetraazacyclododecane-N,N',N″,N‴-tetraacetic acid-d-Phe¹-Tyr³-octreotide (⁶⁸Ga-DOTATOC) is taken up by activated macrophages, which accumulate in active inflammatory lesions. The purpose of this study was to investigate the feasibility of ⁶⁸Ga-DOTATOC PET/CT for assessment of vulnerable plaque, by evaluating correlation between aortic uptake of ⁶⁸Ga-DOTATOC and cardiovascular risk factors.

Methods

Fifty patients with neuroendocrine tumors who underwent ⁶⁸Ga-DOTATOC PET/CT were retrospectively enrolled. The uptakes in the thoracic aorta were measured by two methods: multi-sample region-of-interest (ROI) method and single volume-of-interest (VO

SUBMITTER: Lee R 

PROVIDER: S-EPMC6066488 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature