Evaluation of end-tidal carbon dioxide gradient as a predictor of volume responsiveness in spontaneously breathing healthy adults.

ABSTRACT:

Background

Methods to guide fluid therapy in spontaneously breathing patients are scarce. No studies have reported the accuracy of end-tidal CO₂ (ET-CO₂) to predict volume responsiveness in these patients. We sought to evaluate the ET-CO₂ gradient (ΔET-CO₂) after a passive leg rise (PLR) maneuver to predict volume responsiveness in spontaneously breathing healthy adults.

Methods

We conducted a prospective study in healthy adult human volunteers. A PLR maneuver was performed and cardiac output (CO) was measured by transthoracic echocardiography. ET-CO2 was measured with non-invasive capnographs. Volume responsiveness was defined as an increase in cardiac output (CO) > 12% at 90 s after PLR.

Results

Of the 50 volunteers, 32% w

SUBMITTER: Arango-Granados MC 

PROVIDER: S-EPMC6066588 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature