Osteoblast precursors and inflammatory cells arrive simultaneously to sites of a trabecular-bone injury.

ABSTRACT: Background and purpose - Fracture healing in the shaft is usually described as a sequence of events, starting with inflammation, which triggers mesenchymal tissue formation in successive steps. Most clinical fractures engage cancellous bone. We here describe fracture healing in cancellous bone, focusing on the timing of inflammatory and mesenchymal cell type appearance at the site of injury Material and methods - Rats received a proximal tibial drill hole. A subgroup received clodronate-containing liposomes before or after surgery. The tibiae were analyzed with micro-CT and immunohistochemistry 1 to 7 days after injury. Results - Granulocytes (myeloperoxidase) appeared in moderate numbers within the hole at day 1 and then gradually disappeared. Macrophage expression (CD68) was seen on day

SUBMITTER: Bernhardsson M 

PROVIDER: S-EPMC6066776 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature