Additive contributions of melanopsin and both cone types provide broadband sensitivity to mouse pupil control.

ABSTRACT:

Background

Intrinsically photosensitive retinal ganglion cells (ipRGCs) drive an array of non-image-forming (NIF) visual responses including circadian photoentrainment and the pupil light reflex. ipRGCs integrate extrinsic (rod/cone) and intrinsic (melanopsin) photoreceptive signals, but the contribution of cones to ipRGC-dependent responses remains incompletely understood. Given recent data revealing that cone-derived colour signals influence mouse circadian timing and pupil responses in humans, here we set out to investigate the role of colour information in pupil control in mice.

Results

We first recorded electrophysiological activity from the pretectal olivary nucleus (PON) of anaesthetised mice with a red-shifted cone population (Opn1mw^R) and mice lacking fun

SUBMITTER: Hayter EA 

PROVIDER: S-EPMC6066930 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature