Selection-driven cost-efficiency optimization of transcripts modulates gene evolutionary rate in bacteria.

ABSTRACT:

Background

Most amino acids are encoded by multiple synonymous codons. However, synonymous codons are not used equally, and this biased codon use varies between different organisms. It has previously been shown that both selection acting to increase codon translational efficiency and selection acting to decrease codon biosynthetic cost contribute to differences in codon bias. However, it is unknown how these two factors interact or how they affect molecular sequence evolution.

Results

Through analysis of 1320 bacterial genomes, we show that bacterial genes are subject to multi-objective selection-driven optimization of codon use. Here, selection acts to simultaneously decrease transcript biosynthetic cost and increase transcript translational efficiency, with highly expresse

SUBMITTER: Seward EA 

PROVIDER: S-EPMC6066932 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature