Failure in closure of the anterior neural tube causes left isomerization of the zebrafish epithalamus.

ABSTRACT: Differences between the left and right sides of the brain are present in many animal species. For instance, in humans the left cerebral hemisphere is largely responsible for language and tool use and the right for processing spatial information. Zebrafish have prominent left-right asymmetries in their epithalamus that have been associated with differential left and right eye use and navigational behavior. In wild-type (WT) zebrafish embryos, Nodal pathway genes are expressed in the left side of the pineal anlage. Shortly thereafter, a parapineal organ forms to the left of the pineal. The parapineal organ causes differences in gene expression, neuropil density, and connectivity of the left and right habenula nuclei. In embryos that have an open neural tube, such as embryos that are deficien

SUBMITTER: Lu PN 

PROVIDER: S-EPMC6067013 | biostudies-literature | 2013 Feb

REPOSITORIES: biostudies-literature