Endogenous Protection from Ischemic Brain Injury by Preconditioned Monocytes.

ABSTRACT: Exposure to low-dose lipopolysaccharide (LPS) before cerebral ischemia is neuroprotective in stroke models, a phenomenon termed preconditioning (PC). Although it is well established that LPS-PC induces central and peripheral immune responses, the cellular mechanisms modulating ischemic injury remain unclear. Here, we investigated the role of immune cells in the brain protection afforded by PC and tested whether monocytes may be reprogrammed by ex vivo LPS exposure, thus modulating inflammatory injury after cerebral ischemia in male mice. We found that systemic injection of low-dose LPS induces a Ly6C^hi monocyte response that protects the brain after transient middle cerebral artery occlusion (MCAO) in mice. Remarkably, adoptive transfer of monocytes isolated from precondi

SUBMITTER: Garcia-Bonilla L 

PROVIDER: S-EPMC6067076 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature