Relationship between baseline physical activity assessed by pedometer count and new-onset diabetes in the NAVIGATOR trial.

ABSTRACT:

Objective

Physical activity is related to clinical outcomes, even after adjusting for body mass, but is rarely assessed in randomized clinical trials.

Research design and methods

We conducted an observational analysis of data from the Nateglinide and Valsartan in Impaired Glucose Tolerance Outcomes Research trial, in which a total of 9306 people from 40 countries with impaired glucose tolerance and either cardiovascular disease or cardiovascular risk factors were randomized to receive nateglinide or placebo, in a 2-by-2 factorial design with valsartan or placebo. All were asked to also participate in a detailed lifestyle modification programme and followed-up for a median of 6.4 years with progression to diabetes as a co-primary end point. Seven-day ambulatory activity was a

SUBMITTER: Kraus WE 

PROVIDER: S-EPMC6067333 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature