Costs and effects of on-demand treatment of hereditary angioedema in Italy: a prospective cohort study of 167 patients.

ABSTRACT:

Objectives

To explore treatment behaviours in a cohort of Italian patients with hereditary angioedema due to complement C1-inhibitor deficiency (C1-INH-HAE), and to estimate how effects and costs of treating attacks in routine practice differed across available on-demand treatments.

Design

Cost analyses and survival analyses using attack-level data collected prospectively for 1 year.

Setting

National reference centre for C1-INH-HAE.

Participants

167 patients with proved diagnosis of C1-INH-HAE, who reported data on angioedema attacks, including severity, localisation and duration, treatment received, and use of other healthcare services.

Interventions

Attacks were treated with either icatibant, plasma-derived C1-INH (pdC1-INH) or just supportive care.

SUBMITTER: Federici C 

PROVIDER: S-EPMC6067408 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature