FAM98A promotes proliferation of non-small cell lung cancer cells via the P38-ATF2 signaling pathway.

ABSTRACT:

Background

FAM98A, a novel protein, is expressed in ovarian and colorectal cancer tissues. However, the association between FAM98A expression and the clinicopathological characteristics of non-small cell lung cancer (NSCLC) remains undetermined.

Materials and methods

The FAM98A expression pattern was determined in NSCLC samples and corresponding adjacent normal lung tissues using immunohistochemical staining and Western blotting. The association of FAM98A expression with clinicopathological characteristics was measured in 131 NSCLC samples. Finally, the overexpression and inhibition of FAM98A was performed in the A549 and SPC-A1 cell lines to explore its role in the development of lung cancer.

Results

Western blot analysis of 20 paired NSCLC samples showed that expres

SUBMITTER: Zheng R 

PROVIDER: S-EPMC6067791 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature