Tumor-infiltrating Treg, MDSC, and IDO expression associated with outcomes of neoadjuvant chemotherapy of breast cancer.

ABSTRACT:

Background

Regulatory T cells(Tregs) and myeloid-derived suppressor cells(MDSCs) represent two immunosuppressive cell populations that are important in the establishment and maintenance of cancer immune tolerance. MDSCs can express IDO and promote immune tolerance via expansion of Treg cell.

Method

We use needle biopsy breast cancer tissues prior to neoadjuvant chemotherapy(NCT) staining for CD33, Foxp3 and IDO by immunohistochemistry to evaluate whether they were correlated with subsequent treatment responses in breast cancer.

Results

Expressions of IDO, CD33⁺MDSCs and Foxp3⁺Tregs were correlated with each other. Immunohistochemical double staining revealed that IDO expression in CD33⁺MDSCs was positively correlated with Foxp3^+</

SUBMITTER: Li F 

PROVIDER: S-EPMC6067871 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature