Analysis of clinical and candidate genetic risk factors for postoperative atrial tachycardia after congenital heart surgery in infants.

ABSTRACT:

Background

Atrial tachycardia (AT) after infant congenital heart disease (CHD) surgery is associated with increased mortality. Polymorphisms in PITX2 (rs2200733) and IL6 (rs1800795) are associated with postoperative atrial fibrillation in adults but have not been studied in CHD. The objective was to test the hypothesis that clinical factors and variants in PITX2 and IL6 are associated with postoperative AT in infants with CHD.

Methods

Infants (<1 year of age) undergoing CHD surgery between September 2007 and May 2016 were included. Subjects had daily assessment of telemetry and were genotyped for the 2 variants. Univariate and multivariate analyses were performed to test for factors independently associated with AT.

Results

Of 1,067 enrolled infants, 164 had postopera

SUBMITTER: O'Connor AM 

PROVIDER: S-EPMC6067964 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature