Association Between Risk Factors for Colorectal Cancer and Risk of Serrated Polyps and Conventional Adenomas.

ABSTRACT:

Background & aims

Serrated polyps (SPs) and conventional adenomas are precursor lesions for colorectal cancer (CRC), but they are believed to arise via distinct pathways. We characterized risk factor profiles for SPs and conventional adenomas in a post hoc analysis of data from 3 large prospective studies.

Methods

We collected data from the Nurses' Health Study, the Nurses' Health Study 2, and the Health Professionals Follow-up Study on subjects who developed SPs or conventional adenomas. Our analysis comprised 141,143 participants who had undergone lower gastrointestinal endoscopy, provided updated diet and lifestyle data every 2-4 years, and were followed until diagnosis of a first polyp. We assessed 13 risk factors for CRC in patients with SPs or conventional adenomas and

SUBMITTER: He X 

PROVIDER: S-EPMC6067965 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature