Ontology highlight
ABSTRACT:
SUBMITTER: Shyamsunder P
PROVIDER: S-EPMC6068032 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Haematologica 20180517 8
Maturation of granulocytes is dependent on controlled gene expression by myeloid lineage restricted transcription factors. CEBPE is one of the essential transcription factors required for granulocytic differentiation. Identification of downstream targets of CEBPE is vital to understand better its role in terminal granulopoiesis. In this study, we have identified <i>Card10</i> as a novel target of CEBPE. We show that CEBPE binds to regulatory elements upstream of the murine <i>Card10</i> locus, a ...[more]