The early expansion of anergic NKG2A^pos/CD56^dim/CD16^neg natural killer represents a therapeutic target in haploidentical hematopoietic stem cell transplantation.

ABSTRACT: Natural killer cells are the first lymphocyte population to reconstitute early after non-myeloablative and T cell-replete haploidentical hematopoietic stem cell transplantation with post-transplant infusion of cyclophosphamide. The study herein characterizes the transient and predominant expansion starting from the second week following haploidentical hematopoietic stem cell transplantation of a donor-derived unconventional subset of NKp46^neg-low/CD56^dim/CD16^neg natural killer cells expressing remarkably high levels of CD94/NKG2A. Both transcription and phenotypic profiles indicated that unconventional NKp46^neg-low/CD56^dim/CD16^neg cells are a distinct natural killer cell subpopulation with features of late stage differentiat

SUBMITTER: Roberto A 

PROVIDER: S-EPMC6068034 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature