Quantification of O-(2-[¹⁸F]fluoroethyl)-L-tyrosine kinetics in glioma.

ABSTRACT:

Background

This study identified the optimal tracer kinetic model for quantification of dynamic O-(2-[¹⁸F]fluoroethyl)-L-tyrosine ([¹⁸F]FET) positron emission tomography (PET) studies in seven patients with diffuse glioma (four glioblastoma, three lower grade glioma). The performance of more simplified approaches was evaluated by comparison with the optimal compartment model. Additionally, the relationship with cerebral blood flow-determined by [¹⁵O]H₂O PET-was investigated.

Results

The optimal tracer kinetic model was the reversible two-tissue compartment model. Agreement analysis of binding potential estimates derived from reference tissue input models with the distribution volume ratio (DVR)-1 derived from the plasma input model

SUBMITTER: Koopman T 

PROVIDER: S-EPMC6068050 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature