Effect of bioactive glass nanoparticles on biological properties of PLGA/collagen scaffold.

ABSTRACT: Bioactive glasses have shown some interesting biological properties such as biocompatibility, biodegradation, and angiogenesis in skin tissue engineering. In the current research, the effects of MgO- or CoO-doped 64S bioactive glass with a composition of 64 SiO2-26 CaO-5 P2O5-5 MgO or CoO (mol%) were studied in relation with biological properties of electrospun [poly(lactic-co-glycolic acid) (PLGA)/collagen]. PLGA/collagen samples were rinsed in suspension of bioactive glass nanoparticles in distilled water with a concentration of 0.1 w/v and then freeze dried. Cell adhesion, viability, angiogenesis, and ionic release were performed and tested in culture medium containing fibroblast cells. Attachment and viability of fibroblast cells were increased significantly in bioglass-coated samples,

SUBMITTER: Nokhasteh S 

PROVIDER: S-EPMC6068071 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature