Leukocytosis, prognosis biomarker in locally advanced head and neck cancer patients after chemoradiotherapy.

ABSTRACT:

Objective

To study the prognostic value of leukocyte increase in a retrospective cohort of locally advanced head and neck squamous cell carcinoma (HNSCC) patients receiving definitive concurrent cisplatin and radiation.

Materials and methods

Clinical records of consecutive previously untreated locally advanced HNSCC patients treated in our Institution between March 2006 and October 2012 by concurrent cisplatin (100 mg/m², every 3 weeks) and radiation (70 Gy in 7 weeks) were collected. The prognostic value of pretreatment leukocyte increase was examined, with focus on patterns of relapse and survival. Leukocytosis and neutrophilia were defined as a leukocyte count or a neutrophils count exceeding 10 and 7.5 G/L, respectively.

Results

We identified 193 patien

SUBMITTER: Schernberg A 

PROVIDER: S-EPMC6068078 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature