Comparison of tumor related signaling pathways with known compounds to determine potential agents for lung adenocarcinoma.

ABSTRACT:

Background

This study compared tumor-related signaling pathways with known compounds to determine potential agents for lung adenocarcinoma (LUAD) treatment.

Methods

Kyoto Encyclopedia of Genes and Genomes signaling pathway analyses were performed based on LUAD differentially expressed genes from The Cancer Genome Atlas (TCGA) project and genotype-tissue expression controls. These results were compared to various known compounds using the Connectivity Mapping dataset. The clinical significance of the hub genes identified by overlapping pathway enrichment analysis was further investigated using data mining from multiple sources. A drug-pathway network for LUAD was constructed, and molecular docking was carried out.

Results

After the integration of 57 LUAD-related pathwa

SUBMITTER: Xu S 

PROVIDER: S-EPMC6068465 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature