A Comparative Study of Modern Homology Modeling Algorithms for Rhodopsin Structure Prediction.

ABSTRACT: Rhodopsins are seven α-helical membrane proteins that are of great importance in chemistry, biology, and modern biotechnology. Any in silico study on rhodopsin properties and functioning requires a high-quality three-dimensional structure. Due to particular difficulties with obtaining membrane protein structures from the experiment, in silico prediction of the three-dimensional rhodopsin structure based only on its primary sequence is an especially important task. For the last few years, significant progress was made in the field of protein structure prediction, especially for methods based on comparative modeling. However, the majority of this progress was made for soluble proteins and further investigations are needed to achieve similar progress for membrane proteins. In this paper, we e

SUBMITTER: Nikolaev DM 

PROVIDER: S-EPMC6068592 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature