Clostridium difficile fecal toxin level is associated with disease severity and prognosis.

ABSTRACT:

Background

Antibiotic-associated colitis caused by Clostridium difficile (C. difficile) is the most common cause of hospital-acquired diarrhea. The pathogenesis of C. difficile colitis is mediated by bacterial toxins. C. difficile infection (CDI) severity may be determined by the fecal level of these toxins.

Objective

The objective of this article is to determine whether fecal C. difficile toxin (CDT) levels are associated with disease severity and prognosis.

Methods

A cross-sectional study of patients admitted with CDI in a tertiary center between 2011 and 2015 was conducted. Fecal CDT levels were determined by quantitative ELISA. Severe CDI was defined as a leukocyte count of > 15 × 10³ cells/μl, creatinine levels that d

SUBMITTER: Cohen NA 

PROVIDER: S-EPMC6068787 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature