Coumarin Probe for Selective Detection of Fluoride Ions in Aqueous Solution and Its Bioimaging in Live Cells.

ABSTRACT: We have synthesized novel coumarin-based fluorescent chemosensors for detection of fluoride ions in aqueous solution. The detection mechanism relied on a fluoride-mediated desilylation triggering fluorogenic reaction and a strong interaction between fluoride and the silicon center. In this work, the hydroxyl-decorated coumarins containing oxysilyl moiety have been synthesized through the aldehyde-functionalized coumarins. The optical responses toward fluoride, as well as aqueous stability studies of both aldehyde and hydroxyl functionalized coumarins, have been investigated. Due to the highest fluorescence enhancement upon the addition of fluoride and good stability in aqueous solution, the hydroxyl-decorated coumarin connected with the bulky tert-butyldiphenyloxysilyl group (-OSitBuPh₂) h

SUBMITTER: Chansaenpak K 

PROVIDER: S-EPMC6069086 | biostudies-literature | 2018 Jun

REPOSITORIES: biostudies-literature