<i>Mamu-B*17</i>⁺ Rhesus Macaques Vaccinated with <i>env</i>, <i>vif</i>, and <i>nef</i> Manifest Early Control of SIVmac239 Replication.

ABSTRACT: Certain major histocompatibility complex class I (MHC-I) alleles are associated with spontaneous control of viral replication in human immunodeficiency virus (HIV)-infected people and simian immunodeficiency virus (SIV)-infected rhesus macaques (RMs). These cases of "elite" control of HIV/SIV replication are often immune-mediated, thereby providing a framework for studying anti-lentiviral immunity. In this study, we examined how vaccination impacts SIV replication in RMs expressing the MHC-I allele Mamu-B*17 Approximately 21% of Mamu-B*17⁺ and 50% of Mamu-B*08⁺ RMs control chronic-phase viremia after SIVmac239 infection. Because CD8⁺ T cells targeting Mamu-B*08-restricted SIV epitopes have been implicated in virologic suppression in

SUBMITTER: Martins MA 

PROVIDER: S-EPMC6069176 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature