Randomized clinical trial of high versus low inferior mesenteric artery ligation during anterior resection for rectal cancer.

ABSTRACT:

Background

The optimal level for inferior mesenteric artery ligation during anterior resection for rectal cancer is controversial. The aim of this randomized trial was to clarify whether the inferior mesenteric artery should be tied at the origin (high tie) or distal to the left colic artery (low tie).

Methods

Patients were allocated randomly to undergo either high- or low-tie ligation and were stratified by surgical approach (open or laparoscopic). The primary outcome was the incidence of anastomotic leakage. Secondary outcomes were duration of surgery, blood loss and 5-year overall survival.

Results

Some 331 patients entered the trial between June 2006 and September 2012. The trial was stopped prematurely as recruitment was slow. Seven patients were excluded after r

SUBMITTER: Fujii S 

PROVIDER: S-EPMC6069351 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature