Experimental study of diclofenac and its biliary metabolites on anastomotic healing.

ABSTRACT:

Background

Diclofenac increases the risk of anastomotic leakage, but the underlying mechanism is unknown. As diclofenac is excreted largely as biliary metabolites, the aim of this study was to determine the effect of these metabolites on intestinal anastomoses.

Methods

This was a randomized controlled blinded experiment using 210 male Wistar rats to assess the effect of 'diclofenac bile' on the anastomotic complication score, leak rate and anastomotic strength following oral and parenteral administration of diclofenac. Bile duct and duodenal catheterization techniques were used for diversion and replacement of bile, and biliary diclofenac metabolites were determined.

Results

Replacement of control bile with diclofenac bile resulted in higher anastomotic complication s

SUBMITTER: Yauw STK 

PROVIDER: S-EPMC6069360 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature