Human candidate gene polymorphisms and risk of severe malaria in children in Kilifi, Kenya: a case-control association study.

ABSTRACT:

Background

Human genetic factors are important determinants of malaria risk. We investigated associations between multiple candidate polymorphisms-many related to the structure or function of red blood cells-and risk for severe Plasmodium falciparum malaria and its specific phenotypes, including cerebral malaria, severe malaria anaemia, and respiratory distress.

Methods

We did a case-control study in Kilifi County, Kenya. We recruited as cases children presenting with severe malaria to the high-dependency ward of Kilifi County Hospital. We included as controls infants born in the local community between Aug 1, 2006, and Sept 30, 2010, who were part of a genetics study. We tested for associations between a range of candidate malaria-protective genes and risk for severe malari

SUBMITTER: Ndila CM 

PROVIDER: S-EPMC6069675 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature