Evidence of primary cilia in the developing rat heart.

ABSTRACT:

Background

A transient increase in cytosolic Ca²⁺ (the "Ca²⁺ transient") determines the degree and duration of myocyte force development in the heart. However, we have previously observed that, under the same experimental conditions, the Ca²⁺ transients from isolated cardiac myocytes are reduced in amplitude in comparison to those from multicellular cardiac preparations. We therefore questioned whether the enzymatic cell isolation procedure might remove structures that modulate intracellular Ca²⁺ in some way. Primary cilia are found in a diverse range of cell types, and have an abundance of Ca²⁺-permeable membrane channels that result in Ca²⁺ influx when activated. Although primary cilia are reportedly ubiquitous, th

SUBMITTER: Kaur S 

PROVIDER: S-EPMC6069708 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature