NetControl4BioMed: a pipeline for biomedical data acquisition and analysis of network controllability.

ABSTRACT:

Background

Network controllability focuses on discovering combinations of external interventions that can drive a biological system to a desired configuration. In practice, this approach translates into finding a combined multi-drug therapy in order to induce a desired response from a cell; this can lead to developments of novel therapeutic approaches for systemic diseases like cancer.

Result

We develop a novel bioinformatics data analysis pipeline called NetControl4BioMed based on the concept of target structural control of linear networks. Our pipeline generates novel molecular interaction networks by combining pathway data from various public databases starting from the user's query. The pipeline then identifies a set of nodes that is enough to control a given, user-defin

SUBMITTER: Kanhaiya K 

PROVIDER: S-EPMC6069765 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature