Hints on T cell responses in a fish-parasite model: Enteromyxum leei induces differential expression of T cell signature molecules depending on the organ and the infection status.

ABSTRACT:

Backgroud

Enteromyxum leei is a myxozoan parasite that produces a slow-progressing intestinal disease. This parasite invades the paracellular space of the intestinal epithelium and progresses from the posterior to the anterior intestine. The aim of the present study was to gain insights into fish T cell responses in the gilthead sea bream-E. leei infection model using a PCR-array with 30 signature molecules for different leukocyte responses in head kidney, spleen, anterior and posterior intestine.

Results

The PCR-array results suggest that E. leei induced migration of T cells from head kidney to intestines where T_H1, CTL and T_H17 profiles were activated and kept in balance by the upregulation of regulatory cytokines. These results were partially validat

SUBMITTER: Piazzon MC 

PROVIDER: S-EPMC6069777 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature