Bloodstream infections caused by Klebsiella pneumoniae: prevalence of bla_KPC, virulence factors and their impacts on clinical outcome.

ABSTRACT:

Background

Klebsiella pneumoniae bloodstream infections (BSIs) occur with significant prevalence and high mortality worldwide. Antimicrobial resistance and virulence are two main factors participating in the pathogenicity of K. pneumoniae. Here we investigated the prevalence of bla_KPC and virulence factors in K. pneumoniae isolated from patients with BSIs and their association with clinical outcome.

Methods

The clinical data of 285 K. pneumoniae BSI cases diagnosed from January 2013 to December 2015 in a Chinese university hospital were retrospectively evaluated. The "string test" was performed to identify hypermucoviscous K. pneumoniae (HMKP). bla_KPC, rmpA, magA and serotype-specific genes were detected by PCR amplification. Finally, a Cox proportional

SUBMITTER: Xu M 

PROVIDER: S-EPMC6069789 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature