Inhibition of enterovirus 71 replication and viral 3C protease by quercetin.

ABSTRACT:

Background

Enterovirus 71 (EV71) is one of the major causative agents of hand, foot, and mouth disease (HFMD), which is sometimes associated with severe central nervous system disease in children. There is currently no specific medication for EV71 infection. Quercetin, one of the most widely distributed flavonoids in plants, has been demonstrated to inhibit various viral infections. However, investigation of the anti-EV71 mechanism has not been reported to date.

Methods

The anti-EV71 activity of quercetin was evaluated by phenotype screening, determining the cytopathic effect (CPE) and EV71-induced cells apoptosis. The effects on EV71 replication were evaluated further by determining virus yield, viral RNA synthesis and protein expression, respectively. The mechanism of acti

SUBMITTER: Yao C 

PROVIDER: S-EPMC6069798 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature