Tumor growth activity of duloxetine in Ehrlich carcinoma in mice.

ABSTRACT:

Objective

The objective of this study was to analyze whether duloxetine influences tumor growth in Ehrlich carcinoma. The mice were administered 5 or 30 mg/kg of duloxetine or saline solution. All animals were inoculated with tumor cells. The tumor progression was evaluated by body weight, abdominal circumference, ascites volume and tumor cell count. The effect of duloxetine on immune response was evaluated by lymphoid cells, nitric oxide (NO) production, arginase and superoxide dismutase (SOD) activity and the spleen immunophenotyping.

Results

There was no difference between the groups regarding weight, abdominal circumference, ascites volume and number of tumor cells. Duloxetine increased the cells of the inguinal lymph node. There was no difference in the number of cells

SUBMITTER: Moura ECR 

PROVIDER: S-EPMC6069801 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature