Associations of gender and serum total cholesterol with CD4+ T cell count and HIV RNA load in antiretroviral-naive individuals in Addis Ababa.

ABSTRACT:

Background

Males are more susceptible than females to infections due to the differences in endocrine-immune interactions. Furthermore, it is reported that lowering cell cholesterol impairs viral replication and infection in vitro. However, the production of oxysterols in vivo by oxidation of cholesterol may result in inhibition of HIV replication. Therefore, this study was designed to determine the associations of gender and serum total cholesterol with CD4+ T cell counts and/or WHO clinical stages, and HIV ribonucleic acid (RNA) load in antiretroviral therapy (ART) naive study population with known sero-positive time of stay in Addis Ababa.  METHODS: A cross-sectional study was conducted from February to August 2013 on 594 HIV-1 infected ART-naïve adult study participants in four

SUBMITTER: Adal M 

PROVIDER: S-EPMC6069861 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature