Maternal central obesity and birth size: a Mendelian randomization analysis.

ABSTRACT:

Background

Observational studies have illustrated that maternal central obesity is associated with birth size, including of birth weight, birth length and head circumference, but the causal nature of these associations remains unclear. Our study aimed to test the causal effect of maternal central obesity on birth size and puberty height growth using a Mendelian randomization (MR) analysis.

Methods

We performed two-sample MR using summary-level genome-wide public data. Thirty-five single nucleotide polymorphisms (SNPs), 25 SNPs and 41 SNPs were selected as instrumental variables for waist-to-hip ratio adjusted for BMI, waist circumference adjusted for BMI and hip circumference adjusted for BMI, respectively to test the causal effects of maternal central obesity on birth size

SUBMITTER: Geng TT 

PROVIDER: S-EPMC6069873 | biostudies-literature | 2018 Jul

REPOSITORIES: biostudies-literature