Amyotrophic Lateral Sclerosis and Exposure to Diesel Exhaust in a Danish Cohort.

ABSTRACT: Previous studies have suggested an increased risk of amyotrophic lateral sclerosis (ALS) and other motor neuron diseases for persons in occupations commonly involving exposure to diesel exhaust (DE). In this study, we investigated the association between occupational exposure to DE and odds of ALS. ALS cases were identified from the Danish National Patient Registry (1982-2013) and individually matched to 100 controls per case on the basis of birth year and sex. Using information on occupational history from 1964 onward obtained from the Danish Pension Fund, we estimated cumulative DE exposures using a job exposure matrix. We evaluated associations using conditional logistic regression analyses and stratified the analyses by sex. Using a 10-year lag period, DE exposure was positively associ

SUBMITTER: Dickerson AS 

PROVIDER: S-EPMC6070035 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature