Sensitivity Analyses for Misclassification of Cause of Death in the Parametric G-Formula.

ABSTRACT: Cause-specific mortality is an important outcome in studies of interventions to improve survival, yet causes of death can be misclassified. Here, we present an approach to performing sensitivity analyses for misclassification of cause of death in the parametric g-formula. The g-formula is a useful method to estimate effects of interventions in epidemiologic research because it appropriately accounts for time-varying confounding affected by prior treatment and can estimate risk under dynamic treatment plans. We illustrate our approach using an example comparing acquired immune deficiency syndrome (AIDS)-related mortality under immediate and delayed treatment strategies in a cohort of therapy-naive adults entering care for human immunodeficiency virus infection in the United States. In the s

SUBMITTER: Edwards JK 

PROVIDER: S-EPMC6070049 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature