Peroxiredoxin 6 is the primary antioxidant enzyme for the maintenance of viability and DNA integrity in human spermatozoa.

ABSTRACT:

Study question

Are all components of the peroxiredoxins (PRDXs) system important to control the levels of reactive oxygen species (ROS) to maintain viability and DNA integrity in spermatozoa?

Summary answer

PRDX6 is the primary player of the PRDXs system for maintaining viability and DNA integrity in human spermatozoa.

What is known already

Mammalian spermatozoa are sensitive to high levels of ROS and PRDXs are antioxidant enzymes proven to control the levels of ROS generated during sperm capacitation to avoid oxidative damage in the spermatozoon. Low amounts of PRDXs are associated with male infertility. The absence of PRDX6 promotes sperm oxidative damage and infertility in mice.

Study design, size, duration

Semen samples were obtained over a period of one ye

SUBMITTER: Fernandez MC 

PROVIDER: S-EPMC6070098 | biostudies-literature | 2018 Aug

REPOSITORIES: biostudies-literature