Geospatial distribution of Mycobacterium tuberculosis genotypes in Africa.

ABSTRACT:

Objective

To investigate the distribution of Mycobacterium tuberculosis genotypes across Africa.

Methods

The SITVIT2 global repository and PUBMED were searched for spoligotype and published genotype data respectively, of M. tuberculosis from Africa. M. tuberculosis lineages in Africa were described and compared across regions and with those from 7 European and 6 South-Asian countries. Further analysis of the major lineages and sub-lineages using Principal Component analysis (PCA) and hierarchical cluster analysis were done to describe clustering by geographical regions. Evolutionary relationships were assessed using phylogenetic tree analysis.

Results

A total of 14727 isolates from 35 African countries were included in the analysis and of these 13607 were assigned to

SUBMITTER: Chihota VN 

PROVIDER: S-EPMC6070189 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature