The scale-free nature of protein sequence space.

ABSTRACT: The sequence space of five protein superfamilies was investigated by constructing sequence networks. The nodes represent individual sequences, and two nodes are connected by an edge if the global sequence identity of two sequences exceeds a threshold. The networks were characterized by their degree distribution (number of nodes with a given number of neighbors) and by their fractal network dimension. Although the five protein families differed in sequence length, fold, and domain arrangement, their network properties were similar. The fractal network dimension Df was distance-dependent: a high dimension for single and double mutants (Df = 4.0), which dropped to Df = 0.7-1.0 at 90% sequence identity, and increased to Df = 3.5-4.5 below 70% sequence identity. The distance dependency of the n

SUBMITTER: Buchholz PCF 

PROVIDER: S-EPMC6070207 | biostudies-literature | 2018

REPOSITORIES: biostudies-literature